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A described method for assessing ONOO scavenging involves using a stock solution of dihydroxyrhodamine (5 mM) prepared in dimethylformamide, purged with nitrogen, and stored at 80 C

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Studies using APP/PS1 micea well-established model of Alzheimer's pathologydemonstrate that Dihexa administration restored spatial learning and cognitive functions to near-wildtype levels as measured by Morris water maze performance