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Such an activity reduces L-dopa brain levels, thus decreasing drug beneficial outcomes ( Peptoniphilus , Finegoldia and Enterococcus relative abundance, along with a decrease in Faecalibacterium , Blautia and Lachnospirae relative abundance in comparison with L-dopa-untreated-PD patients, demonstrating that L-dopa, itself can influence gut microbiota composition ( Lactobacillus can reduce L-dopa bioavailability, but at the same time have demonstrated the capacity to slow down PD progression and counteract PD symptoms

A repeat of the same diagnostic test is preferred, though abnormal results on two different tests are also acceptable for diagnosis (OConnor 2015

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