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Intrahepatic fat accumulation and alterations in lipoprotein composition in obese adolescents: A perfect proatherogenic state

Hcv Life Cycle and up-Regulation of Cholesterol and Fatty acid Biosynthesis HCV is a lipid-enveloped, positive-sense, single-stranded RNA virus belonging to the Hepacivirus genus within the Flaviviridae family.30 HCV life cycle is mainly restricted to the liver which plays a key role in cholesterol homeostasis.3,31 Hepatocytes obtain cholesterol by endogenous synthesis via the mevalonate pathway or external sources from the diet (Figure 1).32 In the latter, cholesterol is internalized into the liver by low-density lipoprotein (LDL) ligated to the low-density lipoprotein cholesterol receptor (LDLR).33,34 After infection, HCV enters the bloodstream and binds to the lipoproteins rich in cholesterol esters which contain surface apolipoproteins E and B

Similarly, with the plasma membrane, the current consensus appears to be that much of the cholesterol is in the outer leaflet

(PubMed) Asadi M, Rahimlou M, Shishehbor F, Mansoori A

Report of 3 cases [in Portuguese]