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August 14 Product: Gileads Livdelzi Indication : Primary biliary cholangitis Gilead Sciences $4.3 billion acquisition of CymaBay paid dividends Wednesday after the FDA approved a key asset Livdelzi (seladelpar) to treat patients with primary biliary cholangitis (PBC), an autoimmune liver disease

PMID 22593110

Human safety data is limited, and individual results may vary

Those effects seem to be associated with the increase in expression of sleep-related gamma-aminobutyric acid (GABA) and its receptors - GABA A , GABA B , 5-hydroxytryptamine receptor also known as serotonin receptor (5HT 1A ) and increase in brain GABA content

Tau aggregation is linked to the activity of cellular kinases and phosphatases