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[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

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The study reported that when heifers were fed restricted during early gestation, the supplementation of one-carbon metabolism components increased the thickness of the muscularis externa of fetal small intestine and promoted deeper crypts in the jejunum of the offspring (Daneshi et al., 2025)