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In coronary heart disease, accumulation of atherosclerotic plaque in the coronary arteries may prevent heart regions from getting adequate circulation, ultimately resulting in cardiac damage and impaired pumping ability

In recent years it has come to be used in cosmetic medicine as a technique for facial rejuvenation and for the treatment of alopecia or areas of hyperpigmentation.2 Lipolytic mesotherapy uses various agents with lipolytic activity (mainly phosphatidylcholine and deoxycholate) for the treatment of localized fat deposits in the neck, eyelids, hips, abdomen, or thighs.3 These substances act as detergents, provoking nonspecific damage to the cell wall, with adipocyte necrosis and subsequent inflammatory infiltrate with a predominance initially of neutrophils and later of T lymphocytes, with granulomas and foam cells.4 The final stage is secondary fibrosis in the adipose tissue.5 Although mesotherapy is considered a safe procedure as it is minimally invasive and is usually well tolerated, numerous local and systemic side effects have been reported

Cardiolipin depletion results in reduced complex I, III [90], and IV [96] activity along with the dissociation of subunits VI a and IV b from the complex IV

It can also be found in certain foods like meat, poultry, and dairy

Studies using partially purified canine and bovine NKA (Wood et al., 1977