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Acknowledgments We wish to thank Christine Winterbourn for her critical reading of this manuscript and technical advice on adapting Figure 1 of this manuscript

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Growth promoting actions of IGF-II is via the IGF1R and IGF1R-INSR hybrid receptors which has preference for IGF-II actions if the A isoform of the INSR receptor expressed in the fetus and in malignantly transformed cells - pairs with the IGF1R in the hybrid (106)

Users who stay consistent for eight to twelve weeks report visible improvements in skin density and firmness

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