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Traffic 10 , 17851801 (2009)

The effect of 12 weeks of different exercise training modalities or nutritional guidance on cardiometabolic risk factors, vascular parameters, and physical fitness in overweight adults: cardiometabolic high-intensity interval training-resistance training randomized controlled study

Structurally similar to insulin, IGF-1 binds to specific receptors on cells, activating pathways that promote cell growth, protein synthesis, and repair

Include gradual dose reduction, continued dietary modifications, regular exercise, behavioral support, and potentially transitioning to alternative weight management strategies

Under high temperatures, exogenous SA has been shown to induce the gene expression of PAL and lead to the accumulation of polyphenols in grapes, thus improve resistance to high temperatures [50]