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Studies have shown that TSA downregulates extracellular matrix (ECM) gene transcription and collagen expression in dermal fibroblasts by inhibiting the TGF-/Smad and MAPK/ERK signaling pathways, contributing to its antifibrotic effects (60,61)

Edaravone Edaravone, approved in Japan (2015) and the US (2017), represents another major pharmacological option, particularly indicated for early-stage ALS (23)

93 These findings illustrate the central role of exosomes in promoting stromal renewal through synchronized modulation of proliferative and anti-apoptotic signaling

In Vitro Effects of Curcumin on Proinflammatory Cytokines and Expression of Their Genes in Minor Salivary Gland Tissue of Patients with Sjogrens Syndrome. Rheumatology International, vol

In these cases, she says oral vitamins wouldnt have a great enough effect on their levels, so giving the vitamins intravenously or intramuscularly will bypass the gut and get the vitamins directly into the blood stream where they can then be absorbed into their cells