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Description
Through activation of the Nrf2antioxidant response element (ARE) signaling axis, GSH upregulates cytoprotective enzymes such as heme oxygenase-1, glutathione peroxidase, and NAD(P)H quinone oxidoreductase-1, thereby enhancing cellular resistance to oxidative injury [10]

Many short-term intervention studies in older individuals with vascular diseases have found that therapeutic doses of citicoline given orally, by intramuscular injection, or by intravenous infusion resulted in improvements in neuropsychological functions, including cognitive, emotional, and behavioral functions (reviewed in 5)

Scientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) and energy and vitality (ID 18, 26, 62, 105, 122, 145, 165, 3962, 4054, 4440), invigoration of the body (ID 2383, 2386, 2391, 2393, 2409, 2441, 2463, 2488, 3834, 3883), general health (ID 1313, 3348, 4182, 4613), rejuvenation(ID 3981, 4023), tonic (ID 1703, 3462, 3581, 4418), stimulant (ID 3190, 3506) and metabolic benefits (ID 4438)pursuant to Article 13(1) of Regulation (EC) No 1924/2006
2-HG, 2-hydroxyglutarate

Stress hormones like cortisol can heighten nerve sensitivity, making twitching more likely during challenging periods
