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The accumulation and misfolding of -syn is due in part to post-translation modification, particularly phosphorylation and nitration that can be exacerbated by oxidative stress (Brembati et al., 2023)

These regulatory layers coordinately target key enzymes including PHGDH and PSAT1, adapting their expression, stability and activity to meet the metabolic demands of tumor cells, and the regulatory patterns exhibit obvious cancer-type specificity

81 These discoveries have enabled ASOs to be applied in disease treatment via more diverse mechanisms

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