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Low levels of B12 can lead to hyperpigmentation, vitiligo, pale or jaundiced skin, and premature signs of aging like fine lines and wrinkles

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respectively) or saline was injected intraperitoneally

This review contributes to a better understanding the potential mechanisms of benefit of omega-3 PUFA and may provide useful references for the development of new strategies for the treatment of depressive disorder with omega-3 PUFAs