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In a recent and detailed study, Cheah et al
Survey of the proton affinities of adenine, cytosine, thymine and uracil dideoxyribonucleosides, deoxyribonucleosides and ribonucleosides
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Compared to controls, ALS patient lower motor neurons exhibit significantly lower levels of these epigenetic markers, suggesting an association between TDP-43 and DNA methylation, while changes in glial cell methylation are minimal and primarily affect lower motor neurons (151)
