l carnitine side effects fishy odor tmao Did You Know? Some people report a “fishy” smell after supplementing with L-carnitine. This happens because certain gut bacteria convert to trimethylamine, a malodorous compound found in rotting fish. Stabilizing the enzyme in fish
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Prev Nutr Food Sci
found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis ( coprostanol (a bacterial metabolite of cholesterol) ( Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine
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W.et al (2014)
While they can help prevent or control hypercholesterolemia, they are not a substitute for pharmaceutical interventions in more severe cases
