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Restrictive lung diseases are characterized by a proportional decrease in both forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), resulting in a normal or increased FEV1/FVC ratio alongside a decreased total lung capacity

Human Brain Mapping

In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)

Among the 40 patients evaluable for response, 18 patients met the 12-week PFS primary endpoint, with one patient achieving a PR, and 27 patients achieving SD as the best response (Scott et al., 2022)
