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The accumulation of multiple ACs (especially LCACs) in children with abnormal liver function caused by VPA indicates dysfunction of mitochondrial fatty acid -oxidation

Moreover, the SF12 scores showed a statistically significant difference in both PCS and MCS components, with an early improvement in PCS (detectable after 3 months), that may be particularly useful in treating FMS-related fatigue and physical exhaustion

Physicians who performed baseline and outcome assessments were also blinded to the randomization status

Thirdly, as described above, there is conflicting evidence regarding the dependence on modulations of cardiac metabolism with LCAC treatment

Some physicians suggest that adequate water and fluid intake may maximize the semen volume, but this increase will also be within normal limits
