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The accumulation of multiple ACs (especially LCACs) in children with abnormal liver function caused by VPA indicates dysfunction of mitochondrial fatty acid -oxidation

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Moreover, the SF12 scores showed a statistically significant difference in both PCS and MCS components, with an early improvement in PCS (detectable after 3 months), that may be particularly useful in treating FMS-related fatigue and physical exhaustion

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Physicians who performed baseline and outcome assessments were also blinded to the randomization status

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Thirdly, as described above, there is conflicting evidence regarding the dependence on modulations of cardiac metabolism with LCAC treatment

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Some physicians suggest that adequate water and fluid intake may maximize the semen volume, but this increase will also be within normal limits

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