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Acknowledgements Figures 1, 2, 3 and 4 in this review were created using BioRender.com ( Funding This work was supported by the National Natural Science Foundation of China [grant numbers 81973498 and 81774283], National Science Foundation For Distinguished Young Scholars [grant numbers 82125037], the Joint Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical Group (No

Phase II Conjugation Glutathione binds to these intermediates through conjugation the crucial step that makes toxins water-soluble

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Stimulation of Nrf2 by the lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) is involved in neuro- and cardio-protection against oxidative stress after ischemic preconditioning (Calvert et al., 2009