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Quercetin is an abundant flavonoid in the diet (onion, apple, broccoli and berries) (Esposito et al., 2002) that has been shown to reduce mitochondrial damage in various animal models of OS

It modulates dendritic cell and macrophage activity, improving antigen presentation

The major antigenic determinant recognized by these antibodies consists of a cysteinyl sulfhydryl group (on a peptide or protein) covalently bound ortho- to the hydroxyl group and meta- to the acetamide on 3-(cystein- S -yl) APAP (Potter et al

ZO-1 expression was already reduced compared to wild type in 2-week old Mdr2 / EHBDs

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