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The guidelines do provide a moderate recommendation for patients with disabling or intolerable CIPN, suggesting dose delay, reduction, or chemotherapy cessation, but this is based on expert opinion without supporting data

Is modulation of oxidative stress an answer

10.1093/cvr/cvp092 10.1093/cvr/cvp092 [DOI] [PubMed] [Google Scholar] Lopez JM, Zaghloul NM, Aysolla KR et al (2019) EC-SOD can prevent the chronic stages of pulmonary hypertension induced by hypoxia

It has been shown to work for other types of tendon injury, such as tennis elbow and patellar tendinopathy

However, at least three of the earliest identified molecular markers should be outlined