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[DOI] [PMC free article] [PubMed] 250.Sacco, F., Perfetto, L., Castagnoli, L

Lao H, Zhu Y, Yang M, Wang L, Tang J, Xiong H

Mechanistically, EPA and DHA effectively reduced CUMS-induced expression of IL-1, IL-6, TNF-, microglial marker M Integrin alpha M (CD11b), and increased expression of astrocyte marker glial fibrillary acidic protein (GFAP) by regulating the NF-B/p38 signaling pathway (Yang et al., 2019)

Among the strategies explored to improve HTX absorption and bioavailability is the use of ester derivatives, such as hydroxytyrosyl oleate (HTX-OL), encapsulated in solid lipid nanoparticles, which has been shown to improve cellular absorption, stabilize the molecule, and allow controlled release [75]

Regulatory role of ERS The ER, as the central site for protein synthesis, folding, and modification, plays a pivotal role in the neurodegenerative processes of PD