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(2021) clearly indicated that hydrogen-saturated saline mediates neuroprotection through autophagy via the PI3K/AKT/mTOR pathway during the early and medium stages of rotenone-induced PD in rats
Although not evaluated here, lower intracellular GSH levels would also deactivate the GSH-dependent GPX4, further enhancing ferroptotic cell death (8, 38)
First-pass metabolism: Even glutathione that survives GGT faces hepatic first-pass metabolism
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