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while curcumin exerts potent anti-inflammatory, antiproliferative, and anti-angiogenic effects by blocking the NF-B pathway and downregulating VEGF expression (113)

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179765, 190348, 191718 and 205858) and the Women and Childrens Health Research Institute (WCHRI)

Branco de Oliveira MV, Irikura S, Loureno FHB, Shinsato M, Irikura TCDB, Irikura RB, Albuquerque TVC, Shinsato VN, Orsatti VN, Fontanelli AM, Samegima DAG, Gonalves MVM, Bernab DG (2021) Encephalopathy responsive to thiamine in severe COVID-19 patients

Importantly, this dual engineering approach results in on-target and IgG subclass specific effector molecule engagement, giving rise to a toolbox that can guide design of IgG antibodies with tailored mode-of-action towards a specific target and indication