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However, certain circumstances warrant medical review and potential investigation

When BPC-157 was co-administered with diazepam over 10 days (a protocol that normally produces robust tolerance), tolerance development was prevented and physical dependence was postponed

This can lead to fatigue and weakness

The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers

Furthermore, stiffer blood vessels can have increased permeability and become more likely to develop plaque accumulation, which can lead to further complications (82)