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found that although androgen deprivation therapy inhibited the expression of renal glutaminase (KGA) in the GLS1 subtype, the expression of glutaminase C (GAC) was upregulated in tumor cells, which is an androgen-independent GLS1 subtype with stronger enzymatic activity

The receptor synthesis rate V R can be derived based on the steady-state condition in the absence of ligand and can be expressed as V R = k t R T

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Given the lack of prospective literature, as this study and others are retrospective, further research is needed to confirm the impact of a pharmacist-driven HD-MTX protocol on clinical outcomes