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Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthermia

Conversely, patients with TNF- or IL-6 gene variants may benefit from early anti-inflammatory treatments to mitigate inflammation and protect the retina ( Understanding gene-environment interactions is crucial, as factors like diet, exercise, and socioeconomic status can influence DR onset and progression

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Importantly, NRF2 activity is tightly regulated in a spatially and temporally dependent manner to ensure appropriate cytoprotective responses (Xue et al., 2015)

The mechanistic distinction matters