5-amino-1mq nnmt inhibition mechanism Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation Selective and membrane-permeable small molecule
Description
doi: 10.1093/eurheartj/ehn170
Association between NNMT and T2D Many reports have shown the association between NNMT and T2D
39 A detailed inhibition study is needed to fully characterize the inhibitory activity and mechanism of yuanhuadine
A one-way analysis of variance (ANOVA) with Dunnetts posthoc test was used to compare multiple groups (different inhibitor treatments or concentration effects in cellular assessments) to controls
Perhaps most notably, the researchers observed no adverse effects even at high doses
