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The albumin quotient (Q alb ), a key marker of BBB permeability, has been found to be elevated in several studies involving individuals with preclinical AD, mild cognitive impairment (MCI), and established AD itself (Halliday et al

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Several proteases, including matrix metalloproteainse 2 (MMP-2), have been shown to be upregulated in many cancers [22, 23]

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