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Abbreviations ADMA: Asymmetric dimethylarginine AGE: Advanced glycation end product ALA: Alpha linolenic acid CE: Ceramides DPA: Docosapentaenoic acid EPA: Eicosapentaenoic acid FAME: Fatty acid methyl ester FID: Flame ionization detector GC: Gas chromatography NADH: Nicotinamide adenine dinucleotide NMN: Nicotinamide ribonucleotide PCA: Principal component analysis PE: Phosphatidylethanolamines RF: Random forest SMCS: S-methyl cysteine sulfoxide TAG: Triaglycerol TCA: Tricarboxylic acid UPLC-MS/MS: Ultra-high performance liquid chromatography tandem mass-spectrometry References Lueck D

J., Prez-Valdecantos, D., & Roche, E

doi: 10.1179/2047773215Y.0000000030

The treatment is often well-tolerated, with most patients experiencing only mild swelling or tenderness at the injection site, which typically subsides within a few days

It usually presents with pathological changes of glomerular filtration rate below 15 ml/(min1.73m^2), accompanied by retention of metabolites and toxins, and disturbance of water, electrolyte and acid-base balance as the main clinical features ( The elevated levels of TMAO in the blood of patients with ESRD have profound implications for their health status and comorbidities