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Perform motion analysis by rotating the driver wheel at 10rpm for 1st study and 20 rpm for another study

Some observational data suggested increased risks in certain populations (e.g., 98% higher risk of any psychiatric disorder in one 2024 cohort), while others, including analyses of STEP trials and large registries, found no increased risk or even small reductions in depressive symptoms compared to placebo or other antidiabetics

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[2] During the experimental period, the animal room holds four rats per cage, with free access to water and food, under conditions of temperature controlled at 20-26C, humidity at 40-70%, and a 12/12-h day-night light cycle

Caloric deficit, adequate protein intake, resistance training to preserve lean mass