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DON, at the concentrations used in this study, had no toxic effects in non-tumour-bearing VM/Dk mice, as was shown previously for C57BL/6J mice 33

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Furthermore, another experiment using a knocked-out mouse metallothionein gene showed that when PPE was injected into the trachea of mice, almost no ROS was produced in the lungs of normal mice, but a higher amount was produced in the lungs of mice with the metallothionein gene knocked out [47]

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