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A systematic review and meta-analysis published in the British Journal of Clinical Pharmacology (Rhim et al., 2019) examined multiple trials of L-arginine supplementation

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Furthermore, PALS and PACS were reduced in patients who developed IRAF (PALS 4Ch: 18,896,90 vs 29,409,79, p-value 0,06

It was the first peptide shown to be encoded by mitochondrial DNA that acts as a systemic hormone