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It leads to recurrent epithelial injury, where dysregulated epithelial cells undergo epithelial-mesenchymal transition via multiple signaling pathways, resulting in the excessive release of cytokines and growth factors

Peripheral neuropathy may progress to affect the sensation and function of nerves in the hands, arms, abdomen, and face

Mishra M, Thakur G, Bassi P, Kaur G, Singh TG, Kaur N, et al

The predominant lung cancer subtype, non-small-cell lung cancer (NSCLC), accounts for 80% of lung cancer-associated deaths, and about 70% of patients have locally advanced or metastatic disease at the time of diagnosis
