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The underlined mechanism involves CGA-mediated excessive ROS production, causing mitochondrial dysfunction, leading to increases in cleaved levels of caspase-3, caspase-9, PARP, and Bax/Bcl-2 ratio [297,298]

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In that year and 2023, the FDA and European Medicines Agency (EMA) approved sodium thiosulfate (PEDMARK and Pedmarqsi, respectively) therapy for reducing cisplatin ototoxicity in children suffering from non-metastatic solid tumours [77,78,79,80]

In animal models of autism, notably rats with intrauterine valproic acid injection 11,12 or maternal immune activation 13 , rats carrying the fragile X 11 or MECP2 mutation 14 , acute maternal administration of bumetanide, a NKCC1 chloride-importer inhibitor, before delivery switched the action of GABA from excitatory to inhibitory in the offspring, restoring both electrophysiological profile of the CA3 area of hippocampus, cerebellar purkinje cells or normal cerebral volumes

doi: 10.1046/j.1365-2249.2000.01218.x 141 SimRBMoestrupSKStuartGRLynchNJLuJSchwaebleWJet al