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Beta cell heterogeneity In a seminal study, Bader et al [44] demonstrated that the Wnt/planar cell polarity (PCP) pathway underlies beta cell heterogeneity and controls beta cell maturation

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166 Moreover, oridonin, a tetracyclic diterpenoid extracted from Rabdosia labtea , induced markers associated with apoptosis in gemcitabine-resistant PANC-1 pancreatic cancer cells, while concurrently inhibiting the expression of GSTP1

Absent Fn3K, NRF2 is glycated, a post-translational modification which enhances KEAP1-driven degradation, impairs NRF2 binding to transcriptional cofactors sMAF, reduces NRF2 binding in the promoter region of target genes, and leads to reduced transcription of canonical NRF2 pathway genes [87]