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___ AP video journalist Javier Arciga contributed to this story from San Diego ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institutes Science and Educational Media Group and the Robert Wood Johnson Foundation

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Relax the leg

If you plan to resume, restart at the full dose rather than titrating back up, since the break period allows receptor resensitization

Two separate human clinical trials (ulcerative colitis and multiple sclerosis) proceeded without significant adverse event reporting