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In the heart, nitration of several critical proteins has been proposed as a major mechanism of cardiac dysfunction (995, 1300)

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Non-enzymatic glycation of matrix proteins leads to the accumulation of advanced glycation end-products (AGEs), which form abnormal cross-links that stiffen the ECM and reduce tendon elasticity (Singh et al., 2014

[56] A few years later, Kuske confirmed this hypothesis

Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice
