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Later studies further revealed that this protective function of MTs was achieved by suppressing oxidative stress and inhibiting apoptosis in cardiomyocytes

Hepatic cancer cell line-based models Although PHHs have become the preferred cell source for liver toxicity assessments, the use of immortalized liver cancer cell lines as alternatives to address the limitations of PHHs has been proposed

J Steroid Biochem Mol Biol.2020;198:105562

This includes people who consume alcohol or caffeine or those who take proton pump inhibitors (ex