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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Strange R.C., Spiteri M.A., Ramachandran S., Fryer A.A

Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes

Zanor M

During the pathological changes that occur following IS, JNK gets activated, which in turn enhances the aggregation of pro-apoptotic proteins Bax and Bak, leading to the activation of Caspase-9 and Caspase-3, ultimately resulting in neuronal apoptosis [80, 81]

Such changes in gut microbial diversity can compromise the integrity of the epithelial barrier, leading to leaky gut or dysbiosis, in which increased intestinal permeability permits the passage of bacteria, toxins, and metabolites, thereby causing immune activation and intestinal disorders in the fetus [17]