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doi:10.2337/diabetes.54.6.1615
95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes
It is also not recommended for use in patients suffering from severe Leber hereditary optic neuropathy (inherited form of vision loss), and/or runny nose/nasal blockage
Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance
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