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Description
Furthermore, Mn can induce apoptosis

Khanfar and Al Qaroot, 2020)

This condition primarily affects the dorsal surfaces of the hands and feet, especially areas subject to pressure, such as the terminal phalanges, knees, and elbows

Abotaleb et al., 2020

Functionally, caspases involved in apoptosis have been subclassified into initiator (caspases 8, 9, and 10) and effector (caspases 3, 6, and 7) caspases, the initiator caspases are activated by proapoptotic signals and subsequently coordinate their activities to activate effector caspases (McIlwain et al., 2013)
