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Exposure to contrast dye commonly used in x-ray procedures such as angiograms and CT scans: Sometimes the dye can cause serious problems in the kidneys

In glycemic control clinical trials of tirzepatide injection for type 2 diabetes mellitus (T2DM), acute pancreatitis was confirmed in 13 tirzepatide -treated patients (0.23 cases per 100 patient years) versus 3 in comparator-treated patients (0.11 cases per 100 patient years)

Comprehensive human safety trials have not been completed

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Moreover, Ly6a, which is a marker of TCR-dependent activation, was highly expressed in Th1 cells