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10.1038/s41573-019-0058-8 40 MookherjeeN.HancockR

De-succinylation of mitochondrial and nuclear succinylated proteins has been shown to be catalyzed by two members of the sirtuin family, SIRT5 and SIRT7

Because of its defined peptide sequence and stable analytical profile, FOXO4-DRI has become a reference compound in experimental cellular ageing and protein interaction research models

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amylin signals through the area postrema and is thought to restore leptin sensitivity, an effect that may help counter the bodys defense of a higher fat-mass set point