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Si L, Fu J, Liu W, et al

In addition, despite the mechanistic appeal of antioxidant therapy, its translation remains constrained by major pharmacological barriers, including poor stability, limited bioavailability, suboptimal pharmacokinetics, and inadequate CNS delivery, especially for protein- and enzyme-based antioxidants

A recent study reported that muscimol, by reducing WDR neuronal overactivity suppressed both mechanical allodynia and thermal hyperalgesia in CCI-induced rats [94]

Riboflavin may subsequently be released into the portal blood and to the liver in its free form or as FMN after being transported by RFVT1 (previously hRFT1) and RFVT2 (previously hRTF3), encoded by SLC52A1 and SLC52A2 , respectively, and embedded within the basolateral membrane of the enterocytes [5]

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