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10.1371/journal.pone.0124648 [DOI] [PMC free article] [PubMed] [Google Scholar] 51.Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, Montazeri A

H., Campistol, J., Marti-Herrero, M., Caswill, M., Burlina, A

This results is in agreement with several studies demonstrated that MTX induces oxidative stress in tissues companied with decreased antioxidants levels [38, 69]

The relation between TMAO and chronic disease can be ambiguous, involving kidney function [79], disturbed gut-blood barrier [83], or flavin-containing monooxygenase 3 genotype [84]

However, they cannot enter the mitochondria by themselves