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Intrathecal administration of Org25935 and sarcosine (doses ranging from 3 to 300 ng for Org25935 and 20 to 300 ng for sarcosine) led to a significant increase in both mechanical and thermal pain thresholds in mice, with positive effects observed for up to 10 days post-administration

Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

Discussion Primary astrocyte cultures were used to investigate potential adverse consequences of an exposure of astrocytes to itaconate, DI or OI on cell viability, GSH metabolism and glucose metabolism

From preclinical models to human metabolomics