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The antimicrobial activity of most of the defensins was reduced at increasing salt concentrations or in the presence of bivalent cations [131]

According to research, vitamin D deficiency may contribute to the etiology of periodontal disease by decreasing the host immune response, making it more susceptible to infections like gingivitis and periodontitis

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Additionally, IGF-1 administration has been associated with increased tubular phosphate reabsorption.57,58 In the same way, other clinical studies have reported beneficial effects of recombinant IGF-1 on GFR in ESRD patients scheduled to begin renal replacement therapy or patients undergoing peritoneal dialysis.59,60 In vitro studies have supported the renal protective effects of IGF-1