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In the peroxisome proliferator-activated receptor (PPAR)-induced COPD model, upregulation of GPX3 expression can reduce lung tissue damage caused by oxidative stress (Reddy et al., 2018)

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10.3892/mmr.2018.9315 234 ZhaoD.YuY.ZhaoZ.SharmaR.ReiterR

However, they tend to heal slowly due to several factors: limited blood supply compared to muscle tissue repetitive mechanical stress during daily activity disruption of collagen fibers gradual degeneration over time inflammation that interferes with tissue repair Because tendons rely heavily on collagen for strength and flexibility, healing often depends on rebuilding organized collagen fibers within the tissue

Other Nrf2-dependent genes, including GPX4, GSH and NADPH synthesis genes, as well as epigenetic regulators of lipid hydroperoxides, contribute to its ferroptosis-inhibitory effects (117119)