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doi: 10.3390/molecules22040666 179
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

And calcium cations are necessary for this interaction, where calcium can increase the complexs functional affinity to the receptor[39]

Biomed Res Int 2015
Bobermin LD, da Costa DS, de Moraes ADM et al (2024) Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model