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Proliferating megakaryocytes secrete VEGF along with hematopoietic cytokines, resulting in autocrine stimulation of their growth, increased endothelial proliferation [25]

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Additionally, studies have indicated that GLP-1RAs may directly stimulate acinar cells, leading to increased pancreatic enzyme levels and a potential pathway for the development of pancreatitis 14,15

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Non-invasive Alternative: Nasal sprays provide a less invasive option than injections, potentially improving adherence in long-term research protocols