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Yasuhara and Shingo 2004)
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Nat Rev Nephrol 20:118 Gu J, Chen Y, Tong L, Wang X, Yu D, Wu H (2020) Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects
In this setting, Cys2 is known to increase the activity of betaine-homocysteine methyltransferase-this is the so-called Cys2-sparing effect of Met, which is readily observed when Cys2 is added to a low-Met diet in animal models (20)
A selection pressure for low-producing mutants could also be important over time
